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Publication : Enhancement of memory in cannabinoid CB1 receptor knock-out mice.

First Author  Reibaud M Year  1999
Journal  Eur J Pharmacol Volume  379
Issue  1 Pages  R1-2
PubMed ID  10499380 Mgi Jnum  J:102556
Mgi Id  MGI:3607755 Doi  10.1016/s0014-2999(99)00496-3
Citation  Reibaud M, et al. (1999) Enhancement of memory in cannabinoid CB1 receptor knock-out mice. Eur J Pharmacol 379(1):R1-2
abstractText  We have used cannabinoid CB knock-out mice in a two-trial object recognition test to assess the role of cannabinoid CB receptors in memory. Cannabinoid CB1 knock-out mice are able to retain memory for at least 48 h after the first trial whereas the wild-type controls lose their capacity to retain memory after 24 h. These results suggest that endogenous cannabinoid CB receptors play a crucial role in the process of memory storage and retrieval.
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