| Primary Identifier | MGI:1857661 | Allele Type | Targeted |
| Attribute String | Null/knockout, Reporter | Gene | Del(2Hoxd11-Hoxd13)29Ddu |
| Transmission | Germline | Strain of Origin | 129S2/SvPas |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | This allele involved the use of an embryonic stem cell line carrying an ectopic Hoxd11/lacZ transgene located between the resident Hoxd13 and Evx2 genes and flanked at the 3' end by a unique loxP site. A loxPneoloxP cassette was recombined on the same chromosome, downstream of resident Hoxd11. After treatment with Cre recombinase, the resultant deletion removed Hoxd11, Hoxd12, and Hoxd13, but brought the ectopic Hoxd11/lacZ transgene back to the original Hoxd11 locus. Mice homozygous for this deficiency lacked Hoxd11, Hoxd12, and Hoxd13 loci. |
