| First Author | Yoo KH | Year | 2007 |
| Journal | Biochem Biophys Res Commun | Volume | 356 |
| Issue | 1 | Pages | 85-90 |
| PubMed ID | 17350592 | Mgi Jnum | J:121439 |
| Mgi Id | MGI:3710045 | Doi | 10.1016/j.bbrc.2007.02.103 |
| Citation | Yoo KH, et al. (2007) Inactivation of Mxi1 induces Il-8 secretion activation in polycystic kidney. Biochem Biophys Res Commun 356(1):85-90 |
| abstractText | The Mxi1 proteins are biochemical and biological antagonists of c-myc oncoprotein. It has been reported that the overexpression pattern of c-myc might be similar to a molecular feature of early and late stages of human autosomal dominant polycystic kidney disease. We identified the cyst phenotype in Mxi1-deficient mice aged 6-12 months using H&E staining. Some chemokines containing a protein domain similar to human IL-8, which is associated with the inflammatory response, were subsequently selected from the up-regulated genes. We confirmed the expression level of these chemokines and measured protein concentrations of IL-8 using ELISA in the Mxi1-knockdown cells. IL-8 was found to be significantly increased in Mxi1-knockdown cells. We found that p38 MAP kinase activation was involved in the signal transduction of the Mxi1-inactivated secretion of IL-8. Therefore, we could suggest that the inactivation of Mxi1 leads to the inflammatory response and has the potential to induce polycystic renal disease. |
