| First Author | Takahashi N | Year | 2008 |
| Journal | J Exp Med | Volume | 205 |
| Issue | 8 | Pages | 1755-61 |
| PubMed ID | 18663129 | Mgi Jnum | J:139519 |
| Mgi Id | MGI:3808650 | Doi | 10.1084/jem.20080588 |
| Citation | Takahashi N, et al. (2008) IL-17 produced by Paneth cells drives TNF-induced shock. J Exp Med 205(8):1755-61 |
| abstractText | Tumor necrosis factor (TNF) has very potent antitumor activity, but it also provokes a systemic inflammatory response syndrome that leads to shock, organ failure, and death. Here, we demonstrate that interleukin (IL)-17, a proinflammatory cytokine known to be produced mainly by activated T cells, has a critical role in this process. Antiserum against IL-17 or deletion of Il17r protected mice against a lethal TNF challenge. Serum levels of TNF-induced IL-6 and nitric oxide metabolites were significantly reduced in mice deficient in the IL-17R. TNF-induced leukocyte influx in the small intestine was reduced, and there was no injury to the small intestine. Surprisingly, electron microscopy showed that IL-17 was constitutively present in Paneth cells of the crypts. Upon TNF challenge, the intracellular pool of IL-17 in these cells was drastically reduced, suggesting rapid release of IL-17 from the granules of Paneth cells. Our findings assign a novel role for IL-17 in an acute inflammation and identify Paneth cells as a source of the IL-17 that plays a role in this process. These data indicate that innate immune cytokine responses in the local mucosa may participate in rapidly amplifying responses to systemic inflammatory challenges. |
