| First Author | Mancuso M | Year | 2010 |
| Journal | Int J Cancer | Volume | 127 |
| Issue | 12 | Pages | 2749-57 |
| PubMed ID | 21351254 | Mgi Jnum | J:165388 |
| Mgi Id | MGI:4837078 | Doi | 10.1002/ijc.25293 |
| Citation | Mancuso M, et al. (2010) Protective role of 17beta-estradiol on medulloblastoma development in Patched1 heterozygous mice. Int J Cancer |
| abstractText | Medulloblastoma (MB) is the most common pediatric tumor of the CNS, representing approximately 20% of all childhood CNS tumors. Although in recent years many molecular mechanisms that control MB development have been clarified, the effects of biological factors such as gender on this tumor remain to be explained. Epidemiological data, in fact, indicate a significant difference in the incidence of MB between the two sexes, with considerably higher susceptibility of males than females. Besides this different susceptibility, female gender is also a significant favorable prognostic factor in MB, with girls having a much better outcome. Despite these literature data, there has been little investigation into estrogen influence on MB development. In this study, we evaluated how hormone deficiency resulting from ovariectomy, as well as hormone replacement, influence the development of early and advanced MB stages in Patched1 heterozygous mice, a well characterized mouse model of radiation-induced MB. Susceptibility to MB development was significantly increased in ovariectomized Ptch1(+/-) females, and restored to levels observed in control mice after estrogen replacement. We next investigated the molecular mechanisms by which estrogen might influence tumor progression, and show that ERbeta, but not ERalpha, is involved in modulation of MB development by estrogens. Finally, this study shows that a functional interaction between estrogen- and IGF-I-mediated pathways may be responsible for the effects observed. (c) 2010 UICC. |
