| First Author | King JC | Year | 2009 |
| Journal | Nat Genet | Volume | 41 |
| Issue | 5 | Pages | 524-6 |
| PubMed ID | 19396167 | Mgi Jnum | J:151203 |
| Mgi Id | MGI:4352993 | Doi | 10.1038/ng.371 |
| Citation | King JC, et al. (2009) Cooperativity of TMPRSS2-ERG with PI3-kinase pathway activation in prostate oncogenesis. Nat Genet 41(5):524-6 |
| abstractText | The TMPRSS2-ERG fusion, present in approximately 50% of prostate cancers, is less common in prostatic intraepithelial neoplasia (PIN), raising questions about whether TMPRSS2-ERG contributes to disease initiation. We identified the translational start site of a common TMPRSS2-ERG fusion and showed that transgenic TMPRSS2-ERG mice develop PIN, but only in the context of PI3-kinase pathway activation. TMPRSS2-ERG-positive human tumors are also enriched for PTEN loss, suggesting cooperation in prostate tumorigenesis. |
