| First Author | Suzuki A | Year | 2001 |
| Journal | Immunity | Volume | 14 |
| Issue | 5 | Pages | 523-34 |
| PubMed ID | 11371355 | Mgi Jnum | J:69471 |
| Mgi Id | MGI:1934702 | Doi | 10.1016/s1074-7613(01)00134-0 |
| Citation | Suzuki A, et al. (2001) T cell-specific loss of pten leads to defects in central and peripheral tolerance. Immunity 14(5):523-34 |
| abstractText | PTEN, a tumor suppressor gene, is essential for embryogenesis. We used the Cre-loxP system to generate a T cell-specific deletion of the Pten gene (Pten(flox/-) mice). All Pten(flox/-) mice develop CD4(+) T cell lymphomas by 17 weeks. Pten(flox/-) mice show increased thymic cellularity due in part to a defect in thymic negative selection. Pten(flox/-) mice exhibit elevated levels of B cells and CD4(+) T cells in the periphery, spontaneous activation of CD4(+) T cells, autoantibody production, and hypergammaglobulinemia. Pten(flox/-) T cells hyperproliferate, are autoreactive, secrete increased levels of Th1/Th2 cytokines, resist apoptosis, and show increased phosphorylation of PKB/Akt and ERK. Peripheral tolerance to SEB is also impaired in Pten(flox/-) mice. PTEN is thus an important regulator of T cell homeostasis and self-tolerance. |
