| First Author | Schwarz A | Year | 2005 |
| Journal | J Exp Med | Volume | 201 |
| Issue | 2 | Pages | 173-9 |
| PubMed ID | 15657287 | Mgi Jnum | J:95557 |
| Mgi Id | MGI:3526505 | Doi | 10.1084/jem.20041212 |
| Citation | Schwarz A, et al. (2005) Prevention of UV radiation-induced immunosuppression by IL-12 is dependent on DNA repair. J Exp Med 201(2):173-9 |
| abstractText | The immunostimulatory cytokine IL-12 is able to antagonize immunosuppression induced by solar/ultraviolet (UV) radiation via yet unknown mechanisms. IL-12 was recently found to induce deoxyribonucleic acid (DNA) repair. UV-induced DNA damage is an important molecular trigger for UV-mediated immunosuppression. Thus, we initiated studies into immune restoration by IL-12 to discern whether its effects are linked to DNA repair. IL-12 prevented both UV-induced suppression of the induction of contact hypersensitivity and the depletion of Langerhans cells, the primary APC of the skin, in wild-type but not in DNA repair-deficient mice. IL-12 did not prevent the development of UV-induced regulatory T cells in DNA repair-deficient mice. In contrast, IL-12 was able to break established UV-induced tolerance and inhibited the activity of regulatory T cells independent of DNA repair. These data identify a new mechanism by which IL-12 can restore immune responses and also demonstrate a link between DNA repair and the prevention of UV-induced immunosuppression by IL-12. |
