| First Author | Reitmair AH | Year | 1996 |
| Journal | Cancer Res | Volume | 56 |
| Issue | 16 | Pages | 3842-9 |
| PubMed ID | 8706033 | Mgi Jnum | J:34940 |
| Mgi Id | MGI:82395 | Citation | Reitmair AH, et al. (1996) Spontaneous intestinal carcinomas and skin neoplasms in Msh2-deficient mice. Cancer Res 56(16):3842-9 |
| abstractText | Hereditary nonpolyposis colorectal cancer is associated with defects in DNA mismatch repair. Here, we characterize tumor susceptibility of the recently described Msh2-deficient mouse model. Within the first year of observation, all homozygous mice succumbed to disease, with lymphomas observed in at least 80% of the cases. The majority (70%) of animals 6 months or older developed intestinal neoplasms associated with APC inactivation. Microsatellite instability was more common in carcinomas than in adenomas, but uncommon in normal tissues. Some animals (7%) developed a variety of skin neoplasms analogous to the Muir-Torre syndrome. Msh2-/- mice implicate a direct role for mismatch repair in several neoplasms with striking phenotypic similarities to humans. |
