| First Author | Yalcin F | Year | 2024 |
| Journal | Acta Neuropathol Commun | Volume | 12 |
| Issue | 1 | Pages | 50 |
| PubMed ID | 38566120 | Mgi Jnum | J:346860 |
| Mgi Id | MGI:7619178 | Doi | 10.1186/s40478-024-01754-7 |
| Citation | Yalcin F, et al. (2024) Tumor associated microglia/macrophages utilize GPNMB to promote tumor growth and alter immune cell infiltration in glioma. Acta Neuropathol Commun 12(1):50 |
| abstractText | Tumor-associated microglia and blood-derived macrophages (TAMs) play a central role in modulating the immune suppressive microenvironment in glioma. Here, we show that GPNMB is predominantly expressed by TAMs in human glioblastoma multiforme and the murine RCAS-PDGFb high grade glioma model. Loss of GPNMB in the in vivo tumor microenvironment results in significantly smaller tumor volumes and generates a pro-inflammatory innate and adaptive immune cell microenvironment. The impact of host-derived GPNMB on tumor growth was confirmed in two distinct murine glioma cell lines in organotypic brain slices from GPNMB-KO and control mice. Using published data bases of human glioma, the elevated levels in TAMs could be confirmed and the GPNMB expression correlated with a poorer survival. |
