| First Author | Buonfiglioli A | Year | 2019 |
| Journal | Cell Rep | Volume | 29 |
| Issue | 11 | Pages | 3460-3471.e7 |
| PubMed ID | 31825829 | Mgi Jnum | J:301999 |
| Mgi Id | MGI:6489200 | Doi | 10.1016/j.celrep.2019.11.029 |
| Citation | Buonfiglioli A, et al. (2019) let-7 MicroRNAs Regulate Microglial Function and Suppress Glioma Growth through Toll-Like Receptor 7. Cell Rep 29(11):3460-3471.e7 |
| abstractText | Microglia express Toll-like receptors (TLRs) that sense pathogen- and host-derived factors, including single-stranded RNA. In the brain, let-7 microRNA (miRNA) family members are abundantly expressed, and some have recently been shown to serve as TLR7 ligands. We investigated whether let-7 miRNA family members differentially control microglia biology in health and disease. We found that a subset of let-7 miRNA family members function as signaling molecules to induce microglial release of inflammatory cytokines, modulate antigen presentation, and attenuate cell migration in a TLR7-dependent manner. The capability of the let-7 miRNAs to control microglial function is sequence specific, mapping to a let-7 UUGU motif. In human and murine glioblastoma/glioma, let-7 miRNAs are differentially expressed and reduce murine GL261 glioma growth in the same sequence-specific fashion through microglial TLR7. Taken together, these data establish let-7 miRNAs as key TLR7 signaling activators that serve to regulate the diverse functions of microglia in health and glioma. |
