| First Author | Shawlot W | Year | 1995 |
| Journal | Nature | Volume | 374 |
| Issue | 6521 | Pages | 425-30 |
| PubMed ID | 7700351 | Mgi Jnum | J:24115 |
| Mgi Id | MGI:71875 | Doi | 10.1038/374425a0 |
| Citation | Shawlot W, et al. (1995) Requirement for Lim1 in head-organizer function [see comments]. Nature 374(6521):425-30 |
| abstractText | Lim1 is a homeobox gene expressed in the organizer region of mouse embryos. To investigate the role of Lim1 during embryogenesis, a targeted deletion of the Lim1 gene was generated in embryonic stem cells. Embryos homozygous for the null allele lacked anterior head structures but the remaining body axis developed normally. A partial secondary axis developed anteriorly in some mutant embryos. Lim1 is thus an essential regulator of the vertebrate head organizer. |
