| First Author | Ju C | Year | 2019 |
| Journal | Biochem Biophys Res Commun | Volume | 511 |
| Issue | 3 | Pages | 531-535 |
| PubMed ID | 30819402 | Mgi Jnum | J:291729 |
| Mgi Id | MGI:6443142 | Doi | 10.1016/j.bbrc.2019.02.091 |
| Citation | Ju C, et al. (2019) Poly(ADP-ribose) Polymerase-1 is required for hepatocyte proliferation and liver regeneration in mice. Biochem Biophys Res Commun 511(3):531-535 |
| abstractText | Liver regeneration is an orchestrated cellular response and the mechanisms underlying it have been extensively studied using the partial hepatectomy (PHx) model. Poly(ADP-Ribose) Polymerase-1 (PARP1) is a common enzyme for post-translational modification of proteins. Here, we aimed to determine the role of PARP1 in liver regeneration. We found that PARP1 activity was strongly associated with hepatocyte proliferation after PHx. PARP1 knockout mice showed impaired liver recovery and suppressed hepatocyte proliferation after PHx. Mechanistically, PARP1 knockout repressed YAP activity and inhibited expression of cell cycle-associated proteins in liver tissues. Therefore, our findings highlight specialized roles for PARP1 in regulating hepatocytes proliferation and liver regeneration. |
