| First Author | Silva-Sanchez A | Year | 2023 |
| Journal | Sci Immunol | Volume | 8 |
| Issue | 84 | Pages | eadc9081 |
| PubMed ID | 37327322 | Mgi Jnum | J:341050 |
| Mgi Id | MGI:7517267 | Doi | 10.1126/sciimmunol.adc9081 |
| Citation | Silva-Sanchez A, et al. (2023) Activation of regulatory dendritic cells by Mertk coincides with a temporal wave of apoptosis in neonatal lungs. Sci Immunol 8(84):eadc9081 |
| abstractText | Multiple mechanisms restrain inflammation in neonates, most likely to prevent tissue damage caused by overly robust immune responses against newly encountered pathogens. Here, we identify a population of pulmonary dendritic cells (DCs) that express intermediate levels of CD103 (CD103(int)) and appear in the lungs and lung-draining lymph nodes of mice between birth and 2 weeks of age. CD103(int) DCs express XCR1 and CD205 and require expression of the transcription factor BATF3 for development, suggesting that they belong to the cDC1 lineage. In addition, CD103(int) DCs express CCR7 constitutively and spontaneously migrate to the lung-draining lymph node, where they promote stromal cell maturation and lymph node expansion. CD103(int) DCs mature independently of microbial exposure and TRIF- or MyD88-dependent signaling and are transcriptionally related to efferocytic and tolerogenic DCs as well as mature, regulatory DCs. Correlating with this, CD103(int) DCs show limited ability to stimulate proliferation and IFN-gamma production by CD8(+) T cells. Moreover, CD103(int) DCs acquire apoptotic cells efficiently, in a process that is dependent on the expression of the TAM receptor, Mertk, which drives their homeostatic maturation. The appearance of CD103(int) DCs coincides with a temporal wave of apoptosis in developing lungs and explains, in part, dampened pulmonary immunity in neonatal mice. Together, these data suggest a mechanism by which DCs sense apoptotic cells at sites of noninflammatory tissue remodeling, such as tumors or the developing lungs, and limit local T cell responses. |
