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Allele : Cftr<tm1Eur> cystic fibrosis transmembrane conductance regulator; targeted mutation 1 Erasmus University Rotterdam

Primary Identifier  MGI:1857899 Allele Type  Targeted
Attribute String  Humanized sequence Gene  Cftr
Transmission  Germline Strain of Origin  129P2/OlaHsd
Is Recombinase  false Is Wild Type  false
molecularNote  A "Hit and Run" type method was used to create a three base pair deletion in the gene that eliminated phenylalanine codon 508 (p.F508del), creating a mouse model for the deltaF508 mutation found in human cystic fibrosis patients.
  • mutations:
  • Intragenic deletion
  • synonyms:
  • p.F508del,
  • deltaF508,
  • F508del,
  • c.1524_1526del,
  • F508del,
  • deltaF508,
  • c.1524_1526del,
  • p.F508del
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

0 Driven By

64 Publication categories