| First Author | Shah DK | Year | 2004 |
| Journal | J Immunol | Volume | 172 |
| Issue | 4 | Pages | 2296-306 |
| PubMed ID | 14764698 | Mgi Jnum | J:88047 |
| Mgi Id | MGI:3029054 | Doi | 10.4049/jimmunol.172.4.2296 |
| Citation | Shah DK, et al. (2004) Reduced thymocyte development in sonic hedgehog knockout embryos. J Immunol 172(4):2296-306 |
| abstractText | The Hedgehog family of secreted intercellular signaling molecules are regulators of patterning and organogenesis during animal development. In this study we provide genetic evidence that Sonic Hedgehog (Shh) has a role in the control of murine T cell development. Analysis of Shh(-/-) mouse embryos revealed that Shh regulates fetal thymus cellularity and thymocyte differentiation. Shh is necessary for expansion of CD4(-)CD8(-) double-negative (DN) thymocytes and for efficient transition from the earliest CD44(+)CD25(-) DN population to the subsequent CD44(+)CD25(+) DN population and from DN to CD4(+)CD8(+) double-positive cells. |
