| First Author | Liu Y | Year | 2014 |
| Journal | Nat Commun | Volume | 5 |
| Pages | 5660 | PubMed ID | 25434817 |
| Mgi Jnum | J:316593 | Mgi Id | MGI:6839006 |
| Doi | 10.1038/ncomms6660 | Citation | Liu Y, et al. (2014) Different thresholds of ZEB1 are required for Ras-mediated tumour initiation and metastasis. Nat Commun 5:5660 |
| abstractText | Ras pathway mutation is frequent in carcinomas where it induces expression of the transcriptional repressor ZEB1. Although ZEB1 is classically linked to epithelial-mesenchymal transition and tumour metastasis, it has an emerging second role in generation of cancer-initiating cells. Here we show that Ras induction of ZEB1 is required for tumour initiation in a lung cancer model, and we link this function to repression Pten, whose loss is critical for emergence of cancer-initiating cells. These two roles for ZEB1 in tumour progression can be distinguished by their requirement for different levels of ZEB1. A lower threshold of ZEB1 is sufficient for cancer initiation, whereas further induction is necessary for tumour metastasis. |
