| First Author | Zhang W | Year | 1999 |
| Journal | Immunity | Volume | 10 |
| Issue | 3 | Pages | 323-32 |
| PubMed ID | 10204488 | Mgi Jnum | J:54059 |
| Mgi Id | MGI:1334057 | Doi | 10.1016/s1074-7613(00)80032-1 |
| Citation | Zhang W, et al. (1999) Essential role of LAT in T cell development. Immunity 10(3):323-32 |
| abstractText | The linker molecule LAT is a substrate of the tyrosine kinases activated following TCR engagement. Phosphorylated LAT binds many critical signaling molecules. The central role of this molecule in TCR-mediated signaling has been demonstrated by experiments in a LAT-deficient cell line. To probe the role of LAT in T cell development, the LAT gene was disrupted by targeting. LAT-deficient mice appeared healthy. Flow cytometric analysis revealed normal B cell populations but the absence of any mature peripheral T cells. Intrathymic development was blocked within the CD4- CD8- stage. No gross abnormality of NK or platelet function was observed. LAT is thus critical to both T cell activation and development. |
