| First Author | Moritz A | Year | 2009 |
| Journal | Biochem Biophys Res Commun | Volume | 390 |
| Issue | 1 | Pages | 82-6 |
| PubMed ID | 19781524 | Mgi Jnum | J:155134 |
| Mgi Id | MGI:4412336 | Doi | 10.1016/j.bbrc.2009.09.070 |
| Citation | Moritz A, et al. (2009) Metabotropic glutamate receptor 4 interacts with microtubule-associated protein 1B. Biochem Biophys Res Commun 390(1):82-6 |
| abstractText | The metabotropic glutamate receptor 4 (mGluR4) is a G-protein-coupled receptor that mediates inhibition of neurotransmitter release. Here, we used a proteomic approach to identify novel interaction partners of mGluR4 and report that the cytoplasmic C-terminal tail of mGluR4 interacts with microtubule-associated protein 1B (MAP1B). Binding of MAP1B to mGluR4 is inhibited by Ca(2+)/calmodulin, and MAP1B and mGluR4 colocalize at excitatory synapses in cultured hippocampal neurons. Thus, MAP1B might be implicated in the synaptic trafficking and/or regulation of mGluR4. |
