| First Author | Yokoi M | Year | 1996 |
| Journal | Science | Volume | 273 |
| Issue | 5275 | Pages | 645-7 |
| PubMed ID | 8662555 | Mgi Jnum | J:34606 |
| Mgi Id | MGI:82061 | Doi | 10.1126/science.273.5275.645 |
| Citation | Yokoi M, et al. (1996) Impairment of hippocampal mossy fiber LTD in mice lacking mGluR2. Science 273(5275):645-7 |
| abstractText | Subtype 2 of the metabotropic glutamate receptor (mGluR2) is expressed in the presynaptic elements of hippocampal mossy fiber-CA3 synapses. Knockout mice deficient in mGluR2 showed no histological changes and no alterations in basal synaptic transmission, paired-pulse facilitation, or tetanus-induced long-term potentiation (LTP) at the mossy fiber-CA3 synapses. Long-term depression (LTD) induced by low-frequency stimulation, however, was almost fully abolished. The mutant mice performed normally in water maze learning tasks. Thus, the presynaptic mGluR2 is essential for inducing LTD at the mossy fiber-CA3 synapses, but this hippocampal LTD does not seem to be required for spatial learning. |
