| First Author | Bermingham JR Jr | Year | 1996 |
| Journal | Genes Dev | Volume | 10 |
| Issue | 14 | Pages | 1751-62 |
| PubMed ID | 8698235 | Mgi Jnum | J:34460 |
| Mgi Id | MGI:81917 | Doi | 10.1101/gad.10.14.1751 |
| Citation | Bermingham JR Jr, et al. (1996) Tst-1/Oct-6/SCIP regulates a unique step in peripheral myelination and is required for normal respiration. Genes Dev 10(14):1751-62 |
| abstractText | The terminal differentiation of myelinating glia involves complex interactions that culminate in the formation of myelin. The POU domain transcription factor Tst-1/Oct-6/SCIP is expressed transiently during myelination, and we report here that it has a critical role in this developmental process. Deletion of the Tst-1/Oct-6/SCIP gene produces a severe defect in peripheral myelination by arresting Schwann cell maturation before axonal wrapping. Unexpectedly, the activation of major myelin-specific genes appears to be unaffected by the Tst-1/Oct-6/SCIP mutation, demonstrating that multiple, independently regulated events are required for terminal differentiation of Schwann cells. In addition, aberrant differentiation and migration of specific neurons in Tst-1/Oct-6/SCIP mutant homozygotes is associated with a fatal breathing defect, providing a model for investigating the regulation of pulmonary homeostasis. |
