| First Author | Andoniadou CL | Year | 2013 |
| Journal | Cell Stem Cell | Volume | 13 |
| Issue | 4 | Pages | 433-45 |
| PubMed ID | 24094324 | Mgi Jnum | J:201265 |
| Mgi Id | MGI:5512866 | Doi | 10.1016/j.stem.2013.07.004 |
| Citation | Andoniadou CL, et al. (2013) Sox2 Stem/Progenitor Cells in the Adult Mouse Pituitary Support Organ Homeostasis and Have Tumor-Inducing Potential. Cell Stem Cell 13(4):433-445 |
| abstractText | Sox2+ adult mouse pituitary cells can self-renew and terminally differentiate in vitro, but their physiological role in vivo and possible contribution to oncogenesis remain largely unknown. Using genetic lineage tracing, we show here that the Sox2+ cell compartment of both the embryonic and adult pituitary contains stem/progenitor cells that are able to differentiate into all hormone-producing lineages and contribute to organ homeostasis during postnatal life. In addition, we show that targeted expression of oncogenic beta-catenin in Sox2+ cells gives rise to pituitary tumors, but, unexpectedly, the tumor mass is not derived from the Sox2+ mutation-sustaining cells, suggesting a paracrine role of Sox2+ cells in pituitary oncogenesis. Our data therefore provide in vivo evidence of a role for Sox2+ stem/progenitor cells in long-term physiological maintenance of the adult pituitary, and highlight an unexpected non-cell-autonomous role for these cells in the induction of pituitary tumors. VIDEO ABSTRACT: |
