| First Author | Sun X | Year | 2013 |
| Journal | Mucosal Immunol | Volume | 6 |
| Issue | 6 | Pages | 1191-201 |
| PubMed ID | 23549449 | Mgi Jnum | J:317041 |
| Mgi Id | MGI:6843311 | Doi | 10.1038/mi.2013.18 |
| Citation | Sun X, et al. (2013) CD30L/CD30 is critical for maintenance of IL-17A-producing gammadelta T cells bearing Vgamma6 in mucosa-associated tissues in mice. Mucosal Immunol 6(6):1191-201 |
| abstractText | CD30 ligand (CD30L, CD153), a member of the tumor necrosis factor (TNF) superfamily, and its receptor CD30 are important for differentiation and activation of CD4(+) T helper type 17 (Th17) cells. In this report, we demonstrate that the interleukin 17A (IL-17A)-producing gammadelta T cells normally developed in the fetal thymus, whereas Vgamma1(-)Vgamma4(-) gammadelta T cells expressed Vgamma6/Vdelta1 gene transcript selectively decreased in mucosa-associated tissues in naive CD30KO or CD30LKO mice. Moreover, CD30 and CD30L were expressed preferentially by Vgamma1(-)Vgamma4(-) gammadelta T cells in naive mice. The bacteria clearance was attenuated by the impaired response of the IL-17A-producing gammadelta T cells and decreased infiltration of neutrophils in CD30KO or CD30LKO mice. In vivo administration of agonistic anti-CD30 monoclonal antibody restored the ability of protection against Listeria monocytogenes by enhancing Vgamma1(-)Vgamma4(-) gammadelta T cells producing IL-17A not only in wild-type but also CD30LKO mice. Taken together, it appears that CD30L/CD30 signaling plays an important role in the maintenance and activation of IL-17A-producing gammadelta T cells presumably bearing Vgamma6 in the mucosa-associated tissues of mice. |
