| First Author | Ng L | Year | 2001 |
| Journal | Neuroreport | Volume | 12 |
| Issue | 11 | Pages | 2359-62 |
| PubMed ID | 11496110 | Mgi Jnum | J:103702 |
| Mgi Id | MGI:3610633 | Doi | 10.1097/00001756-200108080-00015 |
| Citation | Ng L, et al. (2001) Audiogenic seizure susceptibility in thyroid hormone receptor beta-deficient mice. Neuroreport 12(11):2359-62 |
| abstractText | As early-onset hypothyroidism produces audiogenic seizure susceptibility (AGS) in rodents, the role of TR alpha 1 and TR beta thyroid hormone receptors in AGS was investigated. AGS occurs in mice lacking specifically TR beta (Thrb(tm1/tm1)) and is marked by early onset and persistence, thereby differing from mouse strains where AGS is age-restricted. Thrb(tm1/tm1) mice display AGS whether on a mixed 129/Sv x C57BL/6J or congenic C57BL/6J background. 27% of wild-type mice on the mixed and 0% on the congenic background exhibited AGS. The inability of Thrb(tm1/tm1) mice to downregulate the response to sustained acoustic stimulation may reside in the brain or in the auditory system itself as Thrb(tm1/tm1) mice also display auditory deficits. The AGS phenotype identifies a novel neurological role for TR beta. |
