| First Author | Hébert G | Year | 2005 |
| Journal | Brain Res Mol Brain Res | Volume | 136 |
| Issue | 1-2 | Pages | 267-70 |
| PubMed ID | 15893609 | Mgi Jnum | J:99360 |
| Mgi Id | MGI:3582025 | Doi | 10.1016/j.molbrainres.2005.01.009 |
| Citation | Hebert G, et al. (2005) A role of IL-1 in MPTP-induced changes in striatal dopaminergic and serotoninergic transporter binding: clues from interleukin-1 type I receptor-deficient mice. Brain Res Mol Brain Res 136(1-2):267-70 |
| abstractText | In mice, the MPTP-induced striatal dopaminergic denervation is followed by a spontaneous partial DAT recovery and by serotoninergic hyperinnervation. We show that IL-1RI-deficient mice have a higher DAT decrease in the ventromedial striatum after MPTP and a higher basal serotoninergic innervation of the whole striatum. These data point to a possible role of IL-1RI in the early MPTP-induced structural or functional remodeling of the nigrostriatal dopamine system. |
