| First Author | Burr KL | Year | 2007 |
| Journal | Mutat Res | Volume | 617 |
| Issue | 1-2 | Pages | 147-51 |
| PubMed ID | 17331550 | Mgi Jnum | J:119981 |
| Mgi Id | MGI:3703647 | Doi | 10.1016/j.mrfmmm.2007.01.010 |
| Citation | Burr KL, et al. (2007) The effects of MSH2 deficiency on spontaneous and radiation-induced mutation rates in the mouse germline. Mutat Res 617(1-2):147-51 |
| abstractText | Mutation rates at two expanded simple tandem repeat (ESTR) loci were studied in the germline of mismatch repair deficient Msh2 knock-out mice. Spontaneous mutation rates in homozygous Msh2(-/-) males were significantly higher than those in isogenic wild-type (Msh2(+/+)) and heterozygous (Msh2(+/-)) mice. In contrast, the irradiated Msh2(-/-) mice did not show any detectable increases in their mutation rate, whereas significant ESTR mutation induction was observed in the irradiated Msh2(+/+) and Msh2(+/-) animals. Considering these data and the results of other publications, we propose that the Msh2-deficient mice possess a mutator phenotype in their germline and somatic tissues while the loss of a single Msh2 allele does not affect the stability of heterozygotes. |
