| First Author | Chen CS | Year | 2021 |
| Journal | J Exp Med | Volume | 218 |
| Issue | 8 | PubMed ID | 34086056 |
| Mgi Jnum | J:358771 | Mgi Id | MGI:6755007 |
| Doi | 10.1084/jem.20202377 | Citation | Chen CS, et al. (2021) Loss of direct adrenergic innervation after peripheral nerve injury causes lymph node expansion through IFN-gamma. J Exp Med 218(8) |
| abstractText | Peripheral nerve injury can cause debilitating disease and immune cell-mediated destruction of the affected nerve. While the focus has been on the nerve-regenerative response, the effect of loss of innervation on lymph node function is unclear. Here, we show that the popliteal lymph node (popLN) receives direct neural input from the sciatic nerve and that sciatic denervation causes lymph node expansion. Loss of sympathetic, adrenergic tone induces the expression of IFN-gamma in LN CD8 T cells, which is responsible for LN expansion. Surgery-induced IFN-gamma expression and expansion can be rescued by beta2 adrenergic receptor agonists but not sensory nerve agonists. These data demonstrate the mechanisms governing the pro-inflammatory effect of loss of direct adrenergic input on lymph node function. |
