| First Author | Pippig SD | Year | 1999 |
| Journal | J Immunol | Volume | 163 |
| Issue | 12 | Pages | 6520-9 |
| PubMed ID | 10586044 | Mgi Jnum | J:58979 |
| Mgi Id | MGI:1350743 | Doi | 10.4049/jimmunol.163.12.6520 |
| Citation | Pippig SD, et al. (1999) Robust B cell immunity but impaired T cell proliferation in the absence of CD134 (OX40). J Immunol 163(12):6520-9 |
| abstractText | CD134 (OX40) is a member of the TNF receptor family that is expressed on activated T lymphocytes. T cells from mice that lack expression of CD134 made strong responses to a range of challenges, but they showed impaired proliferation in response to direct stimulation through the TCR with monoclonal anti-CD3epsilon Ab. CD134-deficient mice controlled infection with Leishmania major, Nippostrongylus brasiliensis, and Theiler's murine encephalomyelitis virus, and they made overtly normal Ab responses to a variety of antigens. Thus, CD134 is not essential for many T cell responses in vivo, nor is it required for the provision of help to B cells. Nonetheless, a subtle role in the regulation of T cell reactivity is suggested by the effect of CD134 deficiency on in vitro T cell responses. |
