| First Author | Song J | Year | 2004 |
| Journal | Nat Immunol | Volume | 5 |
| Issue | 2 | Pages | 150-8 |
| PubMed ID | 14730361 | Mgi Jnum | J:87871 |
| Mgi Id | MGI:3028410 | Doi | 10.1038/ni1030 |
| Citation | Song J, et al. (2004) The costimulation-regulated duration of PKB activation controls T cell longevity. Nat Immunol 5(2):150-8 |
| abstractText | A brief antigenic stimulus can promote T cell proliferation, but the duration and nature of intracellular signals required for survival are unclear. Here we show that in the absence of OX40 costimulation, antigen-activated CD4+ cells are short-lived because the activity of protein kinase B (PKB; also known as Akt) is not maintained over time. Activated T cells that express a dominant-negative variant of PKB also undergo apoptosis, reproducing the OX40-deficient phenotype. In contrast, an active form of PKB prevents downregulation of antiapoptotic proteins in OX40-deficient T cells, rescues antigen-induced cell survival in vivo, and controls inflammation in recall responses. Thus, sustained and periodic PKB signaling has an integral role in regulating T cell longevity. |
