| First Author | Phongsisay V | Year | 2015 |
| Journal | Mol Immunol | Volume | 64 |
| Issue | 1 | Pages | 195-203 |
| PubMed ID | 25530156 | Mgi Jnum | J:223242 |
| Mgi Id | MGI:5648584 | Doi | 10.1016/j.molimm.2014.11.020 |
| Citation | Phongsisay V, et al. (2015) Toll-like receptors recognize distinct proteinase-resistant glycoconjugates in Campylobacter jejuni and Escherichia coli. Mol Immunol 64(1):195-203 |
| abstractText | Campylobacter jejuni causes gastroenteritis and autoimmune neuropathy Guillain-Barre syndrome. The mechanism by which C. jejuni infection results in such the hyperimmunity is not completely understood. Host immunity plays an important role in the disease pathogenesis; however, little is known how immune system recognizes this human pathogen. In this study, we report that Toll-like receptors recognize distinct proteinase K-resistant glycoconjugates in C. jejuni and Escherichia coli. Lipopolysaccharide is solely proteinase-resistant glycoconjugate in E. coli. In contrast, C. jejuni possesses at least five different components that are resistant to proteinase digestion and are capable of inducing NF-kappaB activation through TLR2 and TLR4. Possession of multiple activators of Toll-like receptors may be the unique strategy of C. jejuni to trigger hyperimmunity. |
