| First Author | Takeuchi O | Year | 1999 |
| Journal | Immunity | Volume | 11 |
| Issue | 4 | Pages | 443-51 |
| PubMed ID | 10549626 | Mgi Jnum | J:76115 |
| Mgi Id | MGI:2178646 | Doi | 10.1016/s1074-7613(00)80119-3 |
| Citation | Takeuchi O, et al. (1999) Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 11(4):443-51 |
| abstractText | Toll-like receptor (TLR) 2 and TLR4 are implicated in the recognition of various bacterial cell wall components, such as lipopolysaccharide (LPS). To investigate in vivo roles of TLR2, we generated TLR2-deficient mice. In contrast to LPS unresponsiveness in TLR4-deficient mice, TLR2-deficient mice responded to LPS to the same extent as wild-type mice. TLR2-deficient macrophages were hyporesponsive to several Gram-positive bacterial cell walls as well as Staphylococcus aureus peptidoglycan. TLR4-deficient macrophages lacked the response to Gram-positive lipoteichoic acids. These results demonstrate that TLR2 and TLR4 recognize different bacterial cell wall components in vivo and TLR2 plays a major role in Gram-positive bacterial recognition. |
