| First Author | Wallace ME | Year | 1987 |
| Journal | Mouse News Lett | Volume | 78 |
| Pages | 40-41 | Mgi Jnum | J:14123 |
| Mgi Id | MGI:62299 | Citation | Wallace ME (1987) Polydactyly short tail, Pst. Mouse News Lett 78:40-41 |
| abstractText | Full text of MNL contribution: Polydactyl short-tail, Pst. Two polydactyl mice appeared in the F2 of the outcross to CBA mentioned above. These were mated together and the male was mated to his polydactyl daughter and to a polydactyl female, pypy, from our stock V. These three matings gave norma1:polydactyl progeny as follows, in order: 15:3, 11:3 and 11:18. These progeny were classified at birth and reared to 14 days or more. None showed luxation of the hind feet at any time. Polydactyls from the first two matings were mated to mice from AG/Cam and 129/Cam, and gave norma1:polydactyl progeny respectively : 16:l and 21:7. There was no sex bias in any of the data. These outcross matings show the condition to be dominant. All matings together show that penetrance is poor within the Peru background and in the mixed Peru/AG one, but is probably better in mixed Peru/129 and in +py genotypes. Further matings involving 129 are in progress. So far three newborns from polydactyl x polydactyl parents, at a rate much less than 1/4, have been seen at birth to have paddle-like feet, shortened tail and sacral region, and abdominal swelling apparently due to urine retention. They died within 24 hours. The mutant is thus a new autosomal dominant with variable penetrance, is not luxate or luxoid, and is lethal neonatally from a defect related to skeletal deformity involving the tail and sacral region - somewhat like SdSd. Wallace |
