| First Author | Esni F | Year | 2001 |
| Journal | Dev Biol | Volume | 238 |
| Issue | 1 | Pages | 202-12 |
| PubMed ID | 11784004 | Mgi Jnum | J:72022 |
| Mgi Id | MGI:2151641 | Doi | 10.1006/dbio.2001.0405 |
| Citation | Esni F, et al. (2001) Dorsal pancreas agenesis in N-cadherin- deficient mice. Dev Biol 238(1):202-12 |
| abstractText | Members of the cadherin family of cell adhesion molecules are thought to be crucial regulators of tissue patterning and organogenesis. During pancreatic ontogeny N-cadherin is initially expressed in the pancreatic mesenchyme and later in pancreatic endoderm. Analysis of N-cadherin-deficient mice revealed that these mice suffer from selective agenesis of the dorsal pancreas. Further analysis demonstrated that the mechanism for the lack of a dorsal pancreas involves an essential function of N-cadherin as a survival factor in the dorsal pancreatic mesenchyme. |
