| Primary Identifier | MGI:1861187 | Allele Type | Radiation induced |
| Gene | Ccd | Inheritance Mode | Semidominant |
| Strain of Origin | 101 | Is Recombinase | false |
| Is Wild Type | false |
| description | Induced by gamma irradiation in a 101 strain male. Heterozygotes show striking homology to cleidocranial dysplasia, a skeletal disorder in man. The mutation is fully penetrant in heterozygotes. It causes partial or complete failure of ossification of clavicles, symphysis pubis, and cranial fontanelles. This mutation is lethal in homozygotes (J:14006). |
| molecularNote | Genetic analysis of Ccd mice showed a 2 cM deletion on chromosome 17 in an area of synteny to human 6p. The deletion is flanked on one side by the Tcte1 gene, involves Runx1, but extends further proximally, also deleting Mut. |
