| First Author | Blackburn J | Year | 2015 |
| Journal | J Dent Res | Volume | 94 |
| Issue | 1 | Pages | 121-8 |
| PubMed ID | 25376721 | Mgi Jnum | J:228639 |
| Mgi Id | MGI:5708145 | Doi | 10.1177/0022034514556707 |
| Citation | Blackburn J, et al. (2015) Excess NF-kappaB induces ectopic odontogenesis in embryonic incisor epithelium. J Dent Res 94(1):121-8 |
| abstractText | Nuclear factor kappa B (NF-kappaB) signaling plays critical roles in many physiological and pathological processes, including regulating organogenesis. Down-regulation of NF-kappaB signaling during development results in hypohidrotic ectodermal dysplasia. The roles of NF-kappaB signaling in tooth development, however, are not fully understood. We examined mice overexpressing IKKbeta, an essential component of the NF-kappaB pathway, under keratin 5 promoter (K5-Ikkbeta). K5-Ikkbeta mice showed supernumerary incisors whose formation was accompanied by up-regulation of canonical Wnt signaling. Apoptosis that is normally observed in wild-type incisor epithelium was reduced in K5-Ikkbeta mice. The supernumerary incisors in K5-Ikkbeta mice were found to phenocopy extra incisors in mice with mutations of Wnt inhibitor, Wise. Excess NF-kappaB activity thus induces an ectopic odontogenesis program that is usually suppressed under physiological conditions. |
