| First Author | Cho HS | Year | 2020 |
| Journal | Immunohorizons | Volume | 4 |
| Issue | 2 | Pages | 57-71 |
| PubMed ID | 32034085 | Mgi Jnum | J:297288 |
| Mgi Id | MGI:6469812 | Doi | 10.4049/immunohorizons.1900093 |
| Citation | Cho HS, et al. (2020) CD8(+) T Cells Require ITK-Mediated TCR Signaling for Migration to the Intestine. Immunohorizons 4(2):57-71 |
| abstractText | The Tec kinase IL-2-inducible T cell kinase (ITK) regulates the expression of TCR-induced genes. Itk(-/-) T cell responses are impaired but not absent. ITK inhibition prevented colitis disease progression and impaired T cell migration to the colon in mice. To examine the function of ITK in T cell migration to the intestine, we examined the number of gut T cells in Itk(-/-) mice and then evaluated their expression of gut-homing receptors. Combined with in vitro murine T cell stimulation and in vivo migration assay using congenic B6 mice, we demonstrated an essential role for ITK in T cell migration to the intestine in mice. Reconstitution of Itk(-/-) mouse CD8(+) T cells with IFN regulatory factor 4 restored gut-homing properties, providing mechanistic insight into the function of ITK-mediated signaling in CD8(+) T cell migration to the intestinal mucosa in mice. |
