| First Author | Li LX | Year | 2012 |
| Journal | J Immunol | Volume | 189 |
| Issue | 5 | Pages | 2537-44 |
| PubMed ID | 22851710 | Mgi Jnum | J:189855 |
| Mgi Id | MGI:5447129 | Doi | 10.4049/jimmunol.1200429 |
| Citation | Li LX, et al. (2012) Increased susceptibility to Salmonella infection in signal regulatory protein alpha-deficient mice. J Immunol 189(5):2537-44 |
| abstractText | Recent studies have shed light on the connection between elevated erythropoetin production/spleen erythropoiesis and increased susceptibility to Salmonella infection. In this article, we provide another mouse model, the SIRPalpha-deficient (Sirpalpha(-)/(-)) mouse, that manifests increased erythropoiesis as well as heightened susceptibility to Salmonella infection. Sirpalpha(-)/(-) mice succumbed to systemic infection with attenuated Salmonella, possessing significantly higher bacterial loads in both the spleen and the liver. Moreover, Salmonella-specific Ab production and Ag-specific CD4 T cells were reduced in Sirpalpha(-)/(-) mice compared with wild-type controls. To further characterize the potential mechanism underlying SIRPalpha-dependent Ag-specific CD4 T cell priming, we demonstrate that lack of SIRPalpha expression on dendritic cells results in less efficient Ag processing and presentation in vitro. Collectively, these findings demonstrate an indispensable role of SIRPalpha for protective immunity to Salmonella infection. |
