| First Author | McSorley SJ | Year | 2002 |
| Journal | Immunity | Volume | 16 |
| Issue | 3 | Pages | 365-77 |
| PubMed ID | 11911822 | Mgi Jnum | J:135513 |
| Mgi Id | MGI:3793980 | Doi | 10.1016/s1074-7613(02)00289-3 |
| Citation | McSorley SJ, et al. (2002) Tracking salmonella-specific CD4 T cells in vivo reveals a local mucosal response to a disseminated infection. Immunity 16(3):365-77 |
| abstractText | A novel adoptive transfer system was used to track the fate of naive Salmonella-specific CD4 T cells in vivo. These cells showed signs of activation in the Peyer's patches as early as 3 hr after oral infection. The activated CD4 T cells then produced IL-2 and proliferated in the T cell areas of these tissues before migrating into the B cell-rich follicles. In contrast, Salmonella-specific CD4 T cells were not activated in the spleen and very few of these cells migrated to the liver, despite the presence of bacteria in both organs. These results show that the T cell response to pathogenic Salmonella infection is localized to the gut-associated lymphoid tissue and does not extend efficiently to the major sites of late infection. |
