| First Author | Tsuji M | Year | 2009 |
| Journal | Science | Volume | 323 |
| Issue | 5920 | Pages | 1488-92 |
| PubMed ID | 19286559 | Mgi Jnum | J:145906 |
| Mgi Id | MGI:3836314 | Doi | 10.1126/science.1169152 |
| Citation | Tsuji M, et al. (2009) Preferential generation of follicular B helper T cells from Foxp3+ T cells in gut Peyer's patches. Science 323(5920):1488-92 |
| abstractText | Most of the immunoglobulin A (IgA) in the gut is generated by B cells in the germinal centers of Peyer's patches through a process that requires the presence of CD4+ follicular B helper T(TFH) cells. The nature of these T(FH) cells in Peyer's patches has been elusive. Here, we demonstrate that suppressive Foxp3+CD4+ T cells can differentiate into TFH cells in mouse Peyer's patches. The conversion of Foxp3+ T cells into TFH cells requires the loss of Foxp3 expression and subsequent interaction with B cells. Thus, environmental cues present in gut Peyer's patches promote the selective differentiation of distinct helper T cell subsets, such as TFH cells. |
