| First Author | Watanabe K | Year | 2010 |
| Journal | J Immunol | Volume | 184 |
| Issue | 6 | Pages | 2785-92 |
| PubMed ID | 20142360 | Mgi Jnum | J:160122 |
| Mgi Id | MGI:4453439 | Doi | 10.4049/jimmunol.0901823 |
| Citation | Watanabe K, et al. (2010) Requirement for Runx proteins in IgA class switching acting downstream of TGF-beta 1 and retinoic acid signaling. J Immunol 184(6):2785-92 |
| abstractText | IgA is a specific isotype required for mucosal immunity and is the most abundant Ab produced in vivo. Recently, several inductive signals for IgA class switch recombination have been identified; however, the molecular details of the action of these signals and the specific factors acting in B cells remain elusive. In this study, we show that combination of retinoic acid (RA) and TGF-beta1 with other factors induced a much higher frequency of IgA-switched cells than reported previously. In addition, IgA production is severely impaired in Runx2-Runx3 double-deficient mice. In Runx2-Runx3-deficient B cells, both RA- and TGF-beta1-dependent inductions of alpha germline transcription are completely blocked. These data suggest that Runx proteins play an essential role in IgA class switching acting downstream of RA and TGF-beta1 signaling. |
