| First Author | Wilson NS | Year | 2012 |
| Journal | Cancer Cell | Volume | 22 |
| Issue | 1 | Pages | 80-90 |
| PubMed ID | 22789540 | Mgi Jnum | J:191015 |
| Mgi Id | MGI:5451155 | Doi | 10.1016/j.ccr.2012.05.014 |
| Citation | Wilson NS, et al. (2012) Proapoptotic activation of death receptor 5 on tumor endothelial cells disrupts the vasculature and reduces tumor growth. Cancer Cell 22(1):80-90 |
| abstractText | The proapoptotic death receptor DR5 has been studied extensively in cancer cells, but its action in the tumor microenvironment is not well defined. Here, we uncover a role for DR5 signaling in tumor endothelial cells (ECs). We detected DR5 expression in ECs within tumors but not normal tissues. Treatment of tumor-bearing mice with an oligomeric form of the DR5 ligand Apo2L/TRAIL induced apoptosis in tumor ECs, collapsing blood vessels and reducing tumor growth: Vascular disruption and antitumor activity required DR5 expression on tumor ECs but not malignant cells. These results establish a therapeutic paradigm for proapoptotic receptor agonists as selective tumor vascular disruption agents, providing an alternative, perhaps complementary, strategy to their use as activators of apoptosis in malignant cells. |
