| First Author | Cammas F | Year | 2000 |
| Journal | Development | Volume | 127 |
| Issue | 13 | Pages | 2955-63 |
| PubMed ID | 10851139 | Mgi Jnum | J:62628 |
| Mgi Id | MGI:1859236 | Doi | 10.1242/dev.127.13.2955 |
| Citation | Cammas F, et al. (2000) Mice lacking the transcriptional corepressor TIF1beta are defective in early postimplantation development. Development 127(13):2955-63 |
| abstractText | TIF1beta, a member of the transcriptional intermediary factor 1 family, has been reported to function as a corepressor for the large class of KRAB domain-containing zinc finger proteins of the Kruppel type. To address the biological function of TIF1beta, we have generated TIF1beta-deficient mice by gene disruption. TIF1beta protein was detected in wild-type but not TIF1beta(-/-) blastocysts. Homozygous mutant embryos, which developed normally until the blastocyst stage and underwent uterine implantation, were arrested in their development at the early egg-cylinder stage at about embryonic day (E) 5.5 and were completely resorbed by E8.5. Taken together, these results provide genetic evidence that TIF1beta is a developmental regulatory protein that exerts function(s) essential for early postimplantation development. |
