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Publication : Zinc transporter ZnT3 is involved in memory dependent on the hippocampus and perirhinal cortex.

First Author  Martel G Year  2011
Journal  Behav Brain Res Volume  223
Issue  1 Pages  233-8
PubMed ID  21545813 Mgi Jnum  J:177004
Mgi Id  MGI:5293288 Doi  10.1016/j.bbr.2011.04.020
Citation  Martel G, et al. (2011) Zinc transporter ZnT3 is involved in memory dependent on the hippocampus and perirhinal cortex. Behav Brain Res 223(1):233-8
abstractText  Since zinc transporter ZnT3 is localized to the hippocampus and perirhinal cortex, we used ZnT3 knockout mice (KO) to analyze the role of ZnT3 in memory and behavior dependent on these brain regions. ZnT3KO mice were normal in initial learning in the standard water maze but had difficulty finding a second platform location. The mutants showed increased social interaction but were deficient in social and object recognition memory. These data suggest that ZnT3 is involved in certain types of spatial memory and behavior dependent on the hippocampus and perirhinal cortex.
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