| First Author | Lavoie N | Year | 2011 |
| Journal | J Neurosci | Volume | 31 |
| Issue | 50 | Pages | 18251-65 |
| PubMed ID | 22171030 | Mgi Jnum | J:178904 |
| Mgi Id | MGI:5300617 | Doi | 10.1523/JNEUROSCI.4164-11.2011 |
| Citation | Lavoie N, et al. (2011) Vesicular zinc regulates the Ca2+ sensitivity of a subpopulation of presynaptic vesicles at hippocampal mossy fiber terminals. J Neurosci 31(50):18251-65 |
| abstractText | Synaptic vesicles segregate into functionally diverse subpopulations within presynaptic terminals, yet there is no information about how this may occur. Here we demonstrate that a distinct subgroup of vesicles within individual glutamatergic, mossy fiber terminals contain vesicular zinc that is critical for the rapid release of a subgroup of synaptic vesicles during increased activity in mice. In particular, vesicular zinc dictates the Ca(2+) sensitivity of release during high-frequency firing. Intense synaptic activity alters the subcellular distribution of zinc in presynaptic terminals and decreases the number of zinc-containing vesicles. Zinc staining also appears in endosomes, an observation that is consistent with the preferential replenishment of zinc-enriched vesicles by bulk endocytosis. We propose that functionally diverse vesicle pools with unique membrane protein composition support different modes of transmission and are generated via distinct recycling pathways. |
