| First Author | Kalueff A | Year | 2006 |
| Journal | Neuroreport | Volume | 17 |
| Issue | 7 | Pages | 717-21 |
| PubMed ID | 16641675 | Mgi Jnum | J:108897 |
| Mgi Id | MGI:3625246 | Doi | 10.1097/01.wnr.0000215770.79281.e4 |
| Citation | Kalueff A, et al. (2006) Thalamic calcification in vitamin D receptor knockout mice. Neuroreport 17(7):717-21 |
| abstractText | Vitamin D is a steroid hormone with many important functions in the brain, mediated through the nuclear vitamin D receptor. Here, we report that aging nuclear vitamin D receptor knockout mice demonstrate a symmetric thalamic calcification with numerous Ca/P-containing laminated bodies. These results are consistent with clinical findings showing brain calcification in patients with vitamin D deficiency. Our results suggest that nuclear vitamin D receptor deficiency leads to brain mineralization in vitamin D receptor knockout mice, which may represent an experimental model of intracranial calcification. |
