| First Author | Kalueff AV | Year | 2004 |
| Journal | Neuroreport | Volume | 15 |
| Issue | 8 | Pages | 1271-4 |
| PubMed ID | 15167547 | Mgi Jnum | J:102263 |
| Mgi Id | MGI:3607208 | Doi | 10.1097/01.wnr.0000129370.04248.92 |
| Citation | Kalueff AV, et al. (2004) Increased anxiety in mice lacking vitamin D receptor gene. Neuroreport 15(8):1271-4 |
| abstractText | Vitamin D is a steroid hormone with many important functions in the brain, mediated through the vitamin D nuclear receptor. Numerous human and animal data link vitamin D dysfunctions to various behavioural disorders. To examine this problem, we studied whether genetic ablation of vitamin D receptors in mice may be associated with altered emotional behaviours. Here we show that the receptor-deficient mice demonstrate increased anxiety-like behaviours when subjected to a battery of behavioural tests. These studies suggest that vitamin D and its receptors are an important factor in the brain, whose imbalance may significantly affect emotional behaviour. |
