| First Author | Davideau JL | Year | 2004 |
| Journal | J Steroid Biochem Mol Biol | Volume | 89-90 |
| Issue | 1-5 | Pages | 615-8 |
| PubMed ID | 15225849 | Mgi Jnum | J:91343 |
| Mgi Id | MGI:3046587 | Doi | 10.1016/j.jsbmb.2004.03.117 |
| Citation | Davideau JL, et al. (2004) Dental alveolar bone defects related to Vitamin D and calcium status. J Steroid Biochem Mol Biol 89-90:615-8 |
| abstractText | Vitamin D is important for skeletal development, growth, and homeostasis but has been sparsely studied in the oro-facial bone. Dental alveolar bone anchors teeth to mandible and maxilla bones via a periodontal ligament. Its formation and maintenance are strictly dependent on the presence of tooth organs and it is characterized by a high turnover rate. In order to study the role of Vitamin D and the calcium status on dental alveolar bone formation, microradiographic and histologic comparison of wild-type, Vitamin D receptor null mutant (VDR (-/-) hypo- and normo-calcemic mice and tissues were performed at 2 months. In hypo-calcemic VDR (-/-) mice, alveolar bone was hypomineralized and demonstrated a cellular and matrix organization, similar to the immature woven bone. In normo-calcemic VDR (-/-) mice, mineralization of dental alveolar bone appeared normal, but bone was morphologically abnormal in some specific anatomical locations. These data show that Vitamin D and calcium status may control the formation of dental alveolar bone. The differences of phenotype between hypo- and normo-calcemic VDR null mutant mice suggested a specific Vitamin D control of alveolar bone formation by the Vitamin D nuclear receptor pathway. |
