| First Author | Lézot F | Year | 2002 |
| Journal | Connect Tissue Res | Volume | 43 |
| Issue | 2-3 | Pages | 509-14 |
| PubMed ID | 12489206 | Mgi Jnum | J:103313 |
| Mgi Id | MGI:3609112 | Doi | 10.1080/03008200290000583 |
| Citation | Lezot F, et al. (2002) Cross-talk between Msx/Dlx homeobox genes and vitamin D during tooth mineralization. Connect Tissue Res 43(2-3):509-14 |
| abstractText | Rickets is associated with site-specific disorders of enamel and dentin formation, which may reflect the impact of vitamin D on a morphogenetic pathway. This study is devoted to potential cross-talk between vitamin D and Msx/Dlx transcription factors. We raised the question of a potential link between tooth defects seen in mice with rickets and Msx2 gene misexpression, using mutant mice lacking the nuclear vitamin D receptor as an animal model. Our data showed a modulation of Msx2 expression. In order to search for a functional impact of this Msx2 misexpression secondary to rickets, we focused our attention on osteocalcin as a target gene for both vitamin D and Msx2. Combining Msx2 overexpression and vitamin D addition in vitro, we showed an inhibitory effect on osteocalcin expression in immortalized MO6-G3 odontoblasts. Finally, in the same cells, such combinations appeared to modulate VDR expression outlining the existence of complex cross-regulations between vitamin D and Msx/Dix pathways. |
