| First Author | Tada K | Year | 2001 |
| Journal | J Biol Chem | Volume | 276 |
| Issue | 39 | Pages | 36530-4 |
| PubMed ID | 11479302 | Mgi Jnum | J:120410 |
| Mgi Id | MGI:3706492 | Doi | 10.1074/jbc.M104837200 |
| Citation | Tada K, et al. (2001) Critical roles of TRAF2 and TRAF5 in tumor necrosis factor-induced NF-kappa B activation and protection from cell death. J Biol Chem 276(39):36530-4 |
| abstractText | Tumor necrosis factor (TNF) receptor-associated factors (TRAFs) were identified as signal transducers for the TNF receptor superfamily. However, the exact roles of TRAF2 and TRAF5 in TNF-induced NF-kappaB activation still remain controversial. To address this issue, we generated TRAF2 and TRAF5 double knockout (DKO) mice. TNF- but not interleukin-1-induced nuclear translocation of NF-kappaB was severely impaired in murine embryonic fibroblasts (MEFs) derived from DKO mice. Moreover, DKO MEFs were more susceptible to TNF-induced cytotoxicity than TRAF2 knockout MEFs. Collectively, these results indicate that both TRAF2 and TRAF5 are involved in TNF-induced NF-kappaB activation and protection from cell death. |
