| First Author | Koster MI | Year | 2007 |
| Journal | Cell Cycle | Volume | 6 |
| Issue | 3 | Pages | 269-73 |
| PubMed ID | 17224652 | Mgi Jnum | J:121626 |
| Mgi Id | MGI:3710742 | Doi | 10.4161/cc.6.3.3792 |
| Citation | Koster MI, et al. (2007) Conflicting roles for p63 in skin development and carcinogenesis. Cell Cycle 6(3):269-73 |
| abstractText | Epidermal morphogenesis is a complex process that culminates in the formation of a barrier that protects the organism from environmental substances and dehydration. p63, a transcription factor, is essential for normal epidermal morphogenesis as demonstrated by the failure of mice lacking p63 expression to develop an epidermis. However, since two independently generated p63(-/-) mouse models displayed different phenotypes, the role of p63 in epidermal morphogenesis has remained controversial. Furthermore, the tumor susceptibility phenotypes of both p63(-/-) mouse models were strikingly different. In this review, we discuss these conflicting findings and provide evidence for various roles of p63 in the epidermis under normal and pathological conditions. |
